AOD-9604

What is AOD9604?

AOD9604 is a highly specialized synthetic peptide derived from the C-terminal end of human growth hormone, specifically representing the stabilized analog of the 194-217 amino acid sequence. Originally developed to harness the metabolic and regenerative properties of larger growth-factor-binding proteins, this modified fragment is engineered for enhanced stability and biological activity. Unlike full-length growth hormones, AOD9604 is designed to stimulate specific cellular pathways related to lipid metabolism and tissue repair without inducing systemic growth factor elevations or interfering with glycemic control. This makes it a significant subject of study in the fields of metabolic efficiency and regenerative medicine.

Product Structure

The molecular structure of AOD9604 is a 24-amino acid chain that has been cyclized at the C-terminus to ensure structural integrity and resistance to enzymatic degradation. This modification allows the peptide to maintain its bioactive conformation in various research environments.

• Sequence Formula: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
• Molecular Weight: 2515.7 Daltons
• Physical Appearance: Lyophilized white powder

AOD9604 Research

Current scientific literature highlights the multifaceted role of AOD9604 across several biological systems, primarily focusing on its non-hormonal metabolic influences.

1. AOD9604 and Cellular Metabolism

Extensive investigational studies have explored AOD9604 for its ability to optimize cellular energy production. In longitudinal research models, daily administration of the peptide resulted in a sustained increase in metabolic rate without the development of cellular resistance. Unlike traditional metabolic stimulants, AOD9604 appears to function by upregulating mitochondrial biogenesis. This process increases the number and efficiency of mitochondria within cells, facilitating a transition from energy storage to active utilization. Even in models where primary hormone receptors were absent, the peptide continued to show efficacy, suggesting a direct interaction with the mitochondrial membrane or internal enzymatic pathways.

2. Musculoskeletal Function and Performance

In the context of orthopedics and regenerative science, AOD9604 is studied for its potential to accelerate the repair of connective tissues. When introduced to joint environments, researchers observed a marked increase in the synthesis of type II collagen and proteoglycans. This suggests that the peptide may act as a catalyst for chondrocyte activity, helping to rebuild cartilage density and reduce the presence of inflammatory cytokines. Its ability to promote healing without the side effects associated with steroidal interventions makes it a primary candidate for research into degenerative joint conditions.

3. Cardiovascular Health and Vascular Integrity

Beyond its metabolic profile, AOD9604 has demonstrated a protective effect on the cardiovascular system. Research indicates that the peptide supports the health of the vascular endothelium—the inner lining of blood vessels. By reducing oxidative stress markers within the bloodstream, AOD9604 may help maintain vascular elasticity and prevent the inflammatory cascades that lead to cardiovascular dysfunction. This indicates a secondary, systemic benefit that operates independently of its primary metabolic functions.

Research Summary Table

Focus Area

Primary Mechanism

Observed Research Outcome

Metabolism

Mitochondrial Biogenesis

Increased energy efficiency and lipid utilization

Joint Health

Collagen Synthesis

Cartilage repair and reduced local inflammation

Cardiovascular

Endothelial Support

Reduced oxidative stress and improved vessel health

Safety Profile

Targeted Bioactivity

No impact on glucose or insulin-like growth factor levels

Storage

For long-term stability, AOD9604 should be stored at -20 degrees Celsius in its lyophilized form. Once reconstituted with bacteriostatic water or sterile saline, the solution must be kept refrigerated at 2 to 8 degrees Celsius and used within a short timeframe to prevent degradation. Exposure to direct light and frequent temperature fluctuations should be avoided.