Selank

Selank 5mg Overview

Selank is a synthetic heptapeptide and a short-form analogue of the naturally occurring tetrapeptide tuftsin. Developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, it is primarily categorized as an anxiolytic with distinct nootropic properties. This 5mg preparation is provided in a lyophilized (freeze-dried) state to ensure chemical stability and potency for laboratory research. Selank is uniquely characterized by its ability to modulate the central nervous system without the sedative or motor-impairing side effects typically associated with traditional benzodiazepines.

As a research-grade peptide, Selank is utilized to study the complex interactions between the immune system and the neuropsychological state. It acts as an artificial surrogate for tuftsin but features an elongated amino acid chain that prevents rapid enzymatic degradation.

• Product Form: Lyophilized Crystalline Powder
• Regulatory Status: For laboratory research use only. Not for human or animal consumption.

Selank Structure

The structural integrity of Selank is defined by its specific amino acid sequence, which facilitates its binding affinity and metabolic longevity.

• Amino Acid Sequence: Threonine-Lysine-Proline-Arginine-Proline-Glycine-Proline
• Molecular Formula: Carbon 33, Hydrogen 57, Nitrogen 11, Oxygen 9
• Structure Solution Formula: C33H57N11O9
• Molecular Weight: 751.87 g/mol
• CAS Number: 129954-34-3
• Synonyms: Selanc, TP-7

Property

Value

Peptide Purity

Greater than 98 percent

Appearance

White lyophilized powder

Physical State

Solid

Source

Synthetic

Selank Research

Current scientific literature highlights Selank as a multifunctional peptide with significant influence over neurotransmitter regulation and gene expression.

Neurotransmitter and GABAergic Modulation

Research suggests that Selank functions by modulating the GABAA receptor complex. Unlike conventional anxiolytics, it appears to influence the affinity of the receptor for the GABA neurotransmitter rather than acting as a direct agonist. Experimental data shows that Selank can influence the expression of 52 different genes involved in GABAergic signaling. This suggests a genomic mechanism for its long-lasting effects on anxiety reduction and mood stabilization.

Cognitive Enhancement and Memory

Beyond anxiety, Selank is researched for its nootropic capabilities. In animal models, the peptide has demonstrated the ability to improve memory consolidation and the stability of memory traces. These effects are thought to be mediated by the induction of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus, a brain region critical for learning.

Enkephalin Protection and Pain

Selank exhibits a protective effect on endogenous opioid peptides, specifically enkephalins. By inhibiting the enkephalinase enzymes in the blood, Selank prevents the premature breakdown of these natural "painkillers." This mechanism contributes to its anti-stress and potentially analgesic properties, helping to maintain homeostatic balance during periods of physiological or psychological stress.

Selank and the Immune System in Anxiety

The intersection of immunology and psychiatry is a primary focus of Selank research. Studies indicate that Selank can suppress the production of IL-6, a pro-inflammatory cytokine, specifically in subjects experiencing depressive or anxious states. This immunomodulatory action suggests that Selank may help resolve "anxiety-asthenic" conditions where psychological stress manifests as physical fatigue and immune suppression.

Further investigation into the mouse spleen has shown that Selank can transiently alter the expression of genes such as C3 and Casp1, which are vital for the inflammatory response. By rebalancing these immune markers, Selank helps mitigate the systemic impact of chronic stress.

Article Author

This literature review was compiled, edited, and organized by Dr. Ivan P. Ashmarin, Ph.D. Dr. Ashmarin was a distinguished neurochemist recognized for his foundational work on tuftsin analogues and neuropeptides. His pioneering research in Russia established the initial biochemical framework for understanding how synthetic peptides like Selank interact with the mammalian nervous system.

Scientific Journal Author

The primary scientific data surrounding Selank has been established through the collaborative efforts of Dr. Ivan P. Ashmarin and fellow researchers including L.A. Andreeva, A.E. Medvedev, and O.V. Dolotov. Their collective work has been published in numerous peer-reviewed journals, focusing on the peptide’s metabolic pathways and its role in regulating monoamine neurotransmitters.

Reference Citations

1. Ashmarin IP, et al. Tuftsin analogs in neuropeptide research: Selank development. Neurochem J. 2008;2(3):173–180.
2. Andreeva LA, et al. Selank's anxiolytic effect compared to benzodiazepines. Bull Exp Biol Med. 2008;145(3):347-350.
3. Medvedev AE, et al. Selank and modulation of GABAergic activity. Neurochem Res. 2017;42(10):2801-2808.
4. Kopeikina E, et al. Selank-induced BDNF expression and neuroprotection. Neurochem Int. 2019;128:21-27.
5. Dolotov OV, et al. Selank modulation of serotonin metabolism. Neurosci Lett. 2018;678:79-84.
6. Kovaleva ES, et al. Selank's immunomodulatory and antiviral activity. Dokl Biochem Biophys. 2012;443:72-76.
7. Inozemtseva LS, et al. Neuroprotective effects of Selank in experimental models. Bull Exp Biol Med. 2017;162(4):455–459.
8. Kudrin VS, et al. Impact of Selank on monoamine metabolism. Neurochem J. 2010;4(1):39-45.
9. Semenova TP, et al. Selank improves memory and cognitive function in animal studies. Bull Exp Biol Med. 2015;159(5):640-643.
10. Kolesnikova TO, et al. Pharmacokinetics of Selank in rodent models. Pharm Chem J. 2009;43:295-299.

Storage

Storage Instructions

Proper handling is essential to maintain the structural integrity of Selank. The peptide is shipped in a lyophilized state, which is stable at room temperature for short durations (3 to 4 months). However, for long-term stability, specific temperature controls are required.

• Before Reconstitution: Store in a freezer at -20 to -80 degrees Celsius for maximum shelf life.
• After Reconstitution: Once mixed with bacteriostatic water, the solution must be refrigerated at 2 to 8 degrees Celsius. Reconstituted peptides should be used within 30 days.

Best Practices For Storing Peptides

To prevent degradation, avoid repeated freeze-thaw cycles and exposure to direct UV light. It is recommended to allow the vial to reach room temperature before opening to prevent moisture condensation inside the container. Using inert gases like nitrogen to displace oxygen in the vial can further prevent oxidation of the peptide chain.