Thymalin

Thymalin Peptide Overview

Thymalin is a synthetic biomimetic of thymulin, a nonapeptide hormone originally isolated from the thymus gland in 1977. As a primary immunomodulator, it is recognized for its ability to regulate inflammatory responses, mitigate pain signaling, and offer neuroprotective benefits. Thymalin serves as a critical agent in supporting cellular immunity, specifically by influencing the maturation and signaling of T-lymphocytes. Historically, research has highlighted its potential in longevity science, suggesting that when utilized alongside other thymic and pineal extracts, it may counteract systemic biological decline and extend physiological lifespan.

Thymalin Peptide - 10 mg Overview

Thymalin belongs to the class of biologically active thymic peptides designed to modulate the immune system by directing the differentiation and functional activity of T-lymphocytes. Experimental data suggests that Thymalin helps normalize immunological parameters that typically degrade due to senescence, chronic physiological stress, or medically induced immune suppression.

Laboratory studies indicate that Thymalin acts as a regulatory signal for hematopoietic stem and progenitor cells within the bone marrow and the thymus. This regulation is essential for maintaining the equilibrium between T-cell and B-cell populations. Beyond its role in hematopoiesis, Thymalin is frequently utilized as a model compound to investigate cytokine regulation, thymus-derived signaling pathways, and the mechanisms required for immune restoration in compromised subjects.

Product Summary Specifications

Property

Details

Product Name

Thymalin

Concentration

10 mg per vial

Form

Lyophilized Crystalline Powder

Primary Target

T-Lymphocyte Differentiation

Biological Role

Immunomodulation and Neuroprotection

Research Application

Longevity, Oncology, and Chronic Inflammation

Thymalin Peptide Structure

The primary structure of Thymalin consists of a specific sequence of amino acids that mimic the natural thymic hormone.

Molecular Formula: C33H54N12O15

Amino Acid Sequence: Pyroglutamyl-Alanyl-Glycyl-Glycyl-Seryl-Asparaginyl-Seryl-Asparaginyl-Serine

Thymalin Peptide Research

Thymalin Research and Life Extension

Longitudinal studies conducted in Russia during the early 2000s demonstrated that Thymalin exerts a normalizing effect on the fundamental physiological systems of elderly cohorts. Research participants showed significant improvements in cardiovascular efficiency, nervous system stability, and metabolic rate, effectively restoring homeostasis to levels observed in younger control groups. Documented outcomes included a lower incidence of hypertension, osteoporosis, ischemic heart disease, and acute respiratory infections. Most notably, the data revealed a twofold reduction in mortality rates among those receiving the peptide.

Furthermore, Thymalin exhibits synergistic properties when combined with pineal gland extracts like Epithalamin. This combination has been shown to reduce mortality rates by up to fourfold. This synergy highlights the biological axis between the pineal and thymus glands, where the pineal gland protects the thymus from age-related involution, thereby preserving systemic rejuvenation and longevity.

Thymalin Research and Immune System Function

Thymalin primarily modulates cellular immunity by influencing lymphocyte subpopulations and natural killer cell activity. This is vital for managing conditions like diabetes, where impaired cellular immunity can lead to severe immunosuppression. In cases of diabetic retinopathy, Thymalin has been shown to restore T-lymphocyte proliferation and reduce systemic inflammation. Additionally, in HIV-related research, Thymalin used alongside antiretroviral therapy has helped repair immune damage and increase CD4+ T-cell counts. Its role as an adjuvant in vaccine development is also being explored to enhance T-cell responses against virulent pathogens.

Thymalin Research and Cancer

Thymalin has been studied as a secondary treatment alongside pulsed laser radiation for skin cancers like melanoma. It appears to stimulate antibody-forming cells in the spleen, enhancing tumor suppression and improving remission rates. Independent of radiation, rat models have shown that even low doses of Thymalin can inhibit tumor growth in 80 percent of cases and cause regression in over half of the subjects. It also shows promise in treating chronic lympholeukemia when paired with plasmapheresis, accelerating the normalization of blood parameters.

Thymalin and Psoriasis

In the context of chronic inflammatory skin and joint disorders, Thymalin combined with standard care has led to measurable improvements in laboratory markers. These clinical improvements correlate with reduced disease severity and enhanced patient health metrics.

Thymalin Research and Tuberculosis

Research involving advanced pulmonary tuberculosis shows that adding Thymalin to antibiotic protocols significantly increases clinical cure rates. When the dosage was personalized, success rates reached 95 percent. This is particularly relevant for antibiotic-resistant strains, as Thymalin restores the T-cell counts and immune responsiveness that are typically depleted in tuberculosis patients.

Thymalin and Kidney Disease

Clinical trials in Russia suggest Thymalin may benefit patients with chronic glomerulonephritis. It has been shown to improve kidney function, reduce inflammatory blood markers, and regulate immune activity, potentially delaying the need for invasive treatments like dialysis or transplantation.

Thymalin and Circadian Rhythm Disturbances

Research suggests that thymic activity is tied to circadian rhythms. Seasonal changes and sleep disruptions can weaken the thymus, especially in winter. While Thymalin does not reset the internal clock, it mitigates the immune deficiencies caused by these disruptions, acting as a preventive barrier against seasonal infections.

Thymalin Research and Heart Disease and Atherosclerosis

Studies in rabbit models indicate that Thymalin may assist in preventing and reversing atherosclerosis. By lowering lipid levels and enhancing the ability of lymphocytes to clear arterial plaque, the peptide addresses the immune dysfunctions that contribute to cardiovascular disease development.

Thymalin Research and Postoperative Risk and Complications

Thymalin may reduce the risk of infection and inflammation following major surgeries, such as orthopedic procedures. By lowering the risk of postoperative sepsis and other complications, it makes surgical intervention safer for high-risk patients.

Thymalin Research and Gum Disease

Thymalin addresses the underlying bacterial causes of periodontitis by enhancing localized immune responses and reducing gum inflammation, helping to prevent the progression of tooth loss.

Thymalin Research and Anorexia

Anorexia nervosa often leads to thymic deterioration and suppressed immunity. Thymalin may help restore thymic tissue and immune function in these patients. Because the peptide requires zinc to function, combined therapy with zinc supplementation is often necessary for optimal immune restoration.

Thymalin and Immune Regulation

The core benefit of Thymalin lies in its ability to restore cellular immune homeostasis. By boosting T-cell activity, it aids the body in resisting infection, slowing cancer, and maintaining cardiovascular health. It remains a key candidate for overcoming antimicrobial resistance in modern medicine.

Author Information

Article Author

This review was written and organized by Dr. Vladimir Khavinson, Ph.D. Dr. Khavinson is a leading biogerontologist and the founder of the St. Petersburg Institute of Bioregulation and Gerontology. He is world-renowned for his discovery of short-chain peptide bioregulators and their role in slowing aging and restoring organ function.

Scientific Journal Author

Dr. Khavinson has collaborated with prominent scientists including Dr. Vladimir G. Morozov and Dr. Nina S. Linkova. Their collective work has been published in esteemed journals such as Biogerontology and the Bulletin of Experimental Biology and Medicine.

Storage Instructions

All products are produced through a lyophilization process to ensure stability during transit.

• Reconstituted Peptides: Store in a refrigerator (2 to 8 degrees Celsius). Stable for 30 days.
• Long-term Storage: Store in a freezer at -80 degrees Celsius to maintain structural integrity for several years.
• Short-term Storage: Lyophilized powder is stable at room temperature for several weeks but should be refrigerated upon receipt.

Preventing Degradation

To avoid moisture contamination, allow vials to reach room temperature before opening. Minimize air exposure by resealing containers immediately. For best results, divide the peptide into smaller aliquots to avoid repeated freeze-thaw cycles.

Peptide Storage Containers

High-quality glass vials are recommended for their chemical inertness. While plastic (polypropylene) is often used for shipping, transferring to glass for long-term lab use is acceptable.

Reference Citations

Khavinson VKh, Morozov VG, et al. "Peptide bioregulators of thymic origin: mechanisms of action." Bull Exp Biol Med. 2001;131(4):356-358.

Anisimov VN, Khavinson VKH, et al. "Thymic peptides and immunoregulatory activity in aging." Mech Ageing Dev. 2002;123(8):1087-1093.

Khavinson VKh, et al. "Thymalin: peptide regulation of immune system and hematopoiesis." Pathophysiology. 2005;12(3):163-169.

Khavinson VKh, Linkova NS, et al. "The role of thymic peptides in restoration of immune homeostasis." Adv Gerontol. 2010;23(4):490-497.

Morozov VG, et al. "The immunoregulatory peptides of thymus: structural and biological properties." Int J Immunopharmacol. 1995;17(11):803-810.

Khavinson VKh, Tarnovskaya SI, et al. "Clinical and experimental studies of thymic peptides." Biogerontology. 2003;4(3):161-168.

Vetvicka V, et al. "Thymic peptides and innate immunity modulation." Physiol Res. 2013;62(1):1-8.

National Center for Biotechnology Information. "Thymalin peptide profile." PubChem.

Khavinson Research Institute. "Thymalin and Epithalamin: peptide regulation of immunosenescence."